Table 1. PAI1 expression and overall survival in three breast cancer cohorts.

Cohort	n	Hazard ratio (95% confidence interval)	P
UCSF
All cases	117	1.46 (1.07-1.98)	0.016
Subgroup
LN− cases	50	1.14 (0.52-2.47)	0.746
LN+ cases	67	1.53 (1.06-2.20)	0.023
ER− cases	43	1.65 (1.06-2.58)	0.026
ER+ cases	74	1.33 (0.86-2.07)	0.202
Multivariate*
All cases	114	1.37 (0.98-1.93)	0.068
van de Vijver
All cases	295	1.31 (1.09-1.58)	0.003
Subgroup
LN− cases	151	1.55 (1.21-1.99)	0.001
LN+ cases	144	1.13 (0.84-1.52)	0.427
ER− cases	69	1.08 (0.85-1.38)	0.508
ER+ cases	226	1.34 (0.99-1.83)	0.062
High risk †	180	1.21 (1.01-1.45)	0.042
Multivariate ‡
All cases	295	1.18 (0.98-1.41)	0.083
Miller
All cases	234	0.95 (0.72-1.24)	0.699
Subgroup
LN− cases	149	0.83 (0.55-1.26)	0.381
LN+ cases	77	0.99 (0.70-1.39)	0.957
ER− cases	30	1.93 (0.63-5.88)	0.250
ER+ cases	200	0.90 (0.68-1.19)	0.454
Multivariate§
All cases	223	0.95 (0.72-1.24)	0.708

NOTE: Cox proportional hazards analysis was performed for overall survival using PAI1 expression as a normalized continuous variable. Hazard ratios and 95% confidence intervals are for 1-unit increase in the standard deviation of the log 2 expression of PAI1 (range = 1.11-8.33).

^*Multivariate analyses were adjusted for LN status, tumor size, age at diagnosis, and ER status.

^†Cases with a poor 70-gene prognostic signature (33).

^‡Multivariate analyses were adjusted for LN status and ER status.

^§Multivariate analyses were adjusted for LN status, age at diagnosis, tumor size, and ER status.