Table 1.

Pharmacokinetic parameters calculated from a two-compartment model

Protein	T1/2α, h	T1/2β, h	AUC, h·CPM/mL	CL, mL/h
Mb	0.05	3.0	7.0 × 105	1.43
Mb-N-poly(OEGMA)	2.0	18.0	2.9 × 107	0.035

The data in Fig. 5 were fit to a two-compartment model shown as a solid line, to quantify the elimination and distribution response of Mb and Mb-N-poly(OEGMA).