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A schematic representation of ADK conformational transitions. The open state (Left; PDB ID: 2RH5) is in the apo state. The closed state (Right; PDB ID: 2RGX) is bound to Ap5A nucleotide. The semiopen state (Upper; PDB ID: 2AK3) is in complex with AMP, and its AMP lid is in a closed conformation. The other semiopen state (Lower; PDB ID: 1DVR) is in complex with an ATP analog (phosphodifluoromethylphosphonic acid-adenylate ester), and its ATP lid is in a closed conformation.
