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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Mar 2;1791(9):942–948. doi: 10.1016/j.bbalip.2009.02.010

Fig. 3.

Fig. 3

Hypothetical model in which DGKζ could negatively regulate 7TMR signaling. Upon activation of the 7TMR, β-arrestin is recruited to the receptor along with its bound DGKζ. The DGK terminates DAG signaling by converting this lipid to PA. The PA, in turn, might serve to activate a PtdIns4P 5-kinase (PI5K), which generates PtdIns(4,5)P2. This lipid promotes internalization of the 7TMR to limit access to its ligand.