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. 2009 Aug 25;15:1690–1699.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IVCM images of rabbit CALT after instillations with different PG eye drops. IVCM images of rabbit CALT at H4 after ^BAC+latanoprost (A), ^BAC+travoprost (B), ^BAC+bimatoprost (C), PBS (D), or LCEm (E) instillations. Numerous inflammatory cells were observed infiltrating the periphery and center of the CALT structure, especially after the instillation of ^BAC+latanoprost. LCEm did not induce any obvious inflammatory cell infiltration, as in the PBS-instilled eyes. The scale bar indicates 100 μm. New IVCM scale including CALT description shows the following toxicity order (F): ^BAC+latanoprost > ^BAC+travoprost > ^BAC+bimatoprost at H4. There was no significant difference between the PBS and LCEm groups at all times. The asterisk indicates a p<0.0001 compared with ^BAC+latanoprost. The double asterisk indicates a p<0.003 compared with ^BAC+latanoprost and the sharp indicates a p<0.0002 compared with ^BAC+travoprost.