Figure 6. High-confidence protein interactions in herpesvirus virions.

(A) Schematic map of protein interactions within herpesvirus virions. The viral proteins indicated (or their orthologs) have been shown to be present in virus particles by proteomic analyses [59],[60]. The central nodes indicate capsid proteins, the middle layer tegument proteins and the outer layer glycoproteins. The colour code is the same as in Figure 1B. Indicated are all interactions detected in one of the five species and the width of the edges indicates the number of species in which the interactions were detected. M51 is marked by the red arrow. (B) mCMV M50, M51 and M53 co-localize at the nuclear membrane. CFP-tagged M50, YFP-tagged M51 and DsRed2-tagged M53 were expressed either alone (upper row) or together (lower 2 rows) and analysed by fluorescence or bright field (BF) microscopy.