SAM486A inhibits cell proliferation in p53-wild type NB cells. Cell proliferation rate was determined by tetrazolium-based MTS assay. A, the dose-dependent effect of SAM486A was determined in SK-N-SH, SH-SY5Y, IMR-32, and MYCN-2 cells (± doxycycline; Doxy), at 72 hours. B, cells were left untreated or exposed to 10 μM SAM486A, in the presence or absence of 10 μM Spd and 1 mM aminoguanidine, for 24, 48, and 72 hours. Data represent the mean (± SE) of three independent experiments (n=3).