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. 2009 Jun 18;37(15):e105. doi: 10.1093/nar/gkp526

Figure 3.

Figure 3.

Cell-pool results obtained for proband P2 on the NimbleGen Chromosome 22 Tiling array. (a) Evaluation of the 10-cell pool on the NimbleGen Chromosome 22 Tiling array. The profile shown in the center was obtained with a window size of 5.000 oligos (corresponding to 325 kb). The two largest CNVs show bar codes from black to cyan, demonstrating that the size of the CNVs is in the range of 1.3 Mb or larger (actual sizes: 3 and 1.2 Mb, respectively; compare Figure 1b). In contrast, the largest duplication has a bar code ranging only from black to blue, showing that the size of this CNV is somewhere between 325 and 650 kb (the actual size is 532 kb, Figure 1b). To the left side of this duplication another region at position 26.5 Mb appears to be potentially duplicated. However, the calls are not uninterrupted from black to blue, as there is no pink bar revealing that this CNV call is likely to be an artifact [compare panel (4) in Supplementary Figure 2c]. (b) Hybridization of the 5-cell pool from proband P2 on the NimbleGen Chromosome 22 Tiling array resulted in a CNV recognition pattern similar to that of the 10-cell pool. The algorithm shows the presence of the 255 kb large duplication at position of about 44.7–44.8 (compare Figure 1b), however, the larger 296 and 335 kb duplications were not identified.