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. Author manuscript; available in PMC: 2010 Jun 19.
Published in final edited form as: Circ Res. 2009 May 14;104(12):1390–1398. doi: 10.1161/CIRCRESAHA.108.192773

Figure 4. Structural requirements for quinidine binding are partially conserved for pore block and channel internalization.

Figure 4

(A) Dose-response for HL-1 cells expressing Kv1.5-GFP or the quinidine-insensitive Kv1.5-T480A mutant treated with increasing concentrations of quinidine for 10min at 37°C. (B) Quinidine-induced internalization for HL-1 cells expressing Kv1.5-GFP containing the T480A, I508A, L510A, or V512A mutation treated with 100 μmol/L quinidine for 10min at 37°C. (C) Dose-Response for HL-1 cells expressing Kv1.5-GFP or the Kv1.5-P532L mutant treated as described in (A). * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001 as determined by one-way ANOVA.