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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Cardiovasc Res. 2008 Jan;77(1):19–29. doi: 10.1016/j.cardiores.2007.06.024

Figure 1.

Figure 1

Regulation of eNOS activity and mechanisms for endothelial dysfunction. Several mechanisms can account for endothelial dysfunction, including: (1) changes in eNOS mRNA or protein levels; (2) decreased substrate availability; (3) decreased cofactor availability; (4) improper subcellular localization; (5) abnormal phosphorylation; and (6) scavenging of NO by superoxide (O2−) to form peroxynitrite anion (ONOO−). ADMA, asymmetric dimethylarginine; SOD, superoxide dismutase; PKG, protein kinase G.