TABLE 3.
Genes differentially expressed in BPH compared to CA stromal cells identified by SAM
| Symbol | Fold change | SAM rank | GO annotation |
|---|---|---|---|
| Upregulated in CA | |||
| BACE2 | 5.0 | 1 | Peptide hormone processing |
| SULF1 | 4.4 | 2 | Apoptosis |
| OGN | 7.1 | 3 | Growth factor activity |
| MGP | 2.3 | 4 | Cell differentiation |
| DOCK10 | 4.4 | 5 | Guanyl-nucleotide exchange factor activity |
| THY1 | 3.4 | 6 | Cell surface antigen |
| Upregulated in BPH | |||
| BST1 | 4.2 | 1 | Humoral immune response |
| ARHGAP28 | 3.8 | 2 | Viral release |
| OLR1 | 2.3 | 3 | Proteolysis and peptidolysis |
| COL4A5 | 5.0 | 4 | Extracellular matrix structural constituent |
| TOX | 5.0 | 6 | Regulation of transcription |
| IGF-2 | 10.2 | 7 | Cell proliferation/regulation of cell cycle |
| SLC6A6 | 6.1 | 8 | Taurine:sodium symporter activity |
| TEK | 6.4 | 9 | Cell-cell signaling/signal transduction |
| KMO | 2.5 | 10 | Electron transport |
| C11orf30 | 2.0 | 11 | DNA repair/regulation of transcription |
| LOC492304 | 6.7 | 12 | Insulin-like growth factor binding |
| TBL1X | 2.5 | 14 | Regulation of transcription |
| CHN1 | 3.7 | 15 | GTPase activator activity |
| SLC4A4 | 5.7 | 16 | Sodium:bicarbonate symporter activity |
| MFHAS1 | 2.3 | 17 | Small GTPase mediated signal transduction |
| TERF1 | 2.0 | 18 | Cell cycle/regulation of transcription |
| FARP1 | 2.1 | 19 | Rho guanyl-nucleotide exchange factor activity |
| MPP3 | 3.5 | 20 | Guanylate kinase activity/signal transduction |
| VAMP5 | 2.8 | 21 | Cell differentiation/vesicle-mediated transport |
| SSH2 | 2.2 | 22 | Protein amino acid dephosphorylation |
| GTF2E1 | 1.9 | 24 | Regulation of transcription |
| SIPA1L2 | 2.6 | 27 | GTPase activator activity |
| NRG2 | 6.4 | 28 | Anti-apoptosis/cell-cell signaling |
| MYO6 | 2.0 | 29 | ATPase activity/structural constituent of muscle |