TABLE 4.
Genes upregulated in CA compared to PZ stromal cells identified by SAM
| Symbol | Fold change | SAM rank | GO annotation |
|---|---|---|---|
| ENPP2 | 7.4 | 1 | Chemotaxis/transcription factor binding |
| TM4SF3 | 3.6 | 2 | Signal transducer activity |
| SEPT6 | 3.7 | 6 | Cell cycle |
| ICAM4 | 2.3 | 8 | Cell-cell adhesion |
| LOC91431 | 1.8 | 12 | Zinc ion binding |
| ADCK1 | 2.4 | 13 | Protein amino acid phosphorylation |
| DLL3 | 3.3 | 15 | Cell fate determination |
| CMRF35 | 2.9 | 16 | Cellular defense response |
| P2RY1 | 1.8 | 18 | G-protein signaling |
| LRRC7 | 2.0 | 19 | Protein binding |
| DYRK2 | 1.9 | 21 | Protein amino acid phosphorylation |
| LOC400713 | 1.9 | 22 | Regulation of transcription |
| WDR7 | 2.2 | 23 | Cell cycle/apoptosis |
| NAGA | 2.9 | 25 | Carbohydrate metabolism |
| NF1 | 2.3 | 27 | Ras protein signal transduction/cell cycle |
| C16orf34 | 2.4 | 28 | Regulation of transcription |
| HSPD1 | 2.0 | 29 | Response to unfolded protein |
| MICAL2 | 2.3 | 30 | Electron transport |
| C6orf68 | 2.4 | 31 | Metabolism | transferase activity |
| IGF-1 | 1.9 | 32 | Positive regulation of cell proliferation |
| BCL2A1 | 2.5 | 34 | Anti-apoptosis |
| CRY1 | 2.1 | 36 | DNA repair/G-protein coupled photoreceptor activity |
| FRAG1 | 1.6 | 37 | Receptor activity |
| NISCH | 1.7 | 38 | Intracellular signaling cascade |
| FBXW8 | 2.1 | 39 | Ubiquitin cycle |
| TRIM33 | 1.7 | 40 | Regulation of transcription/ubiquitin-protein ligase activity |
| PDE3B | 2.0 | 41 | Signal transduction |
| LMO2 | 4.4 | 42 | Zinc ion binding |
| SLC5A8 | 1.8 | 45 | Transporter activity |
| UGT2B7 | 4.2 | 49 | Lipid metabolism |
| MCM5 | 2.6 | 51 | Regulation of cell cycle/regulation of transcription |
| TAC1 | 2.7 | 52 | Cell-cell signaling |
| SPRY3 | 2.0 | 54 | Regulation of signal transduction |
| LTB4R | 1.8 | 55 | Inflammatory response/signal transduction |
| PKIB | 3.7 | 56 | cAMP-dependent protein kinase inhibitor activity |
| KCTD13 | 1.8 | 59 | Voltage-gated potassium channel activity |
| ATF6 | 1.8 | 64 | Regulation of transcription/signal transduction |
| EBF | 1.9 | 65 | Regulation of transcription |
| MARCH-I | 2.2 | 66 | Protein ubiquitination |
| PANX2 | 1.7 | 67 | Gap junction |
| FLJ22405 | 2.2 | 68 | Protein amino acid dephosphorylation |
| LGR4 | 1.9 | 69 | G-protein coupled receptor protein signaling pathway |
| XAB1 | 2.3 | 71 | Small GTPase mediated signal transduction |
| CA12 | 2.7 | 72 | One-carbon compound metabolism |
| MUC5B | 1.9 | 74 | Cell adhesion |
| RERG | 1.9 | 75 | Cell proliferation/signal transduction |
| LOC126295 | 1.7 | 76 | Regulation of transcription |
| GATA6 | 3.7 | 77 | Regulation of transcription |
| FGFR1 | 1.9 | 78 | Cell growth/FGF receptor signaling pathway |
| ARGBP2 | 2.1 | 79 | Structural constituent of muscle |
| ERBB2 | 1.8 | 81 | Cell proliferation |
| COL4A2 | 1.9 | 83 | Cell adhesion |
| NUP160 | 2.0 | 84 | mRNA-nucleus export |
| LIMS3 | 3.2 | 85 | Zinc ion binding |
| AKR1B10 | 2.1 | 86 | Aldehyde metabolism/electron transporter |
| OGN | 1.9 | 88 | Growth factor activity |
| NRK | 1.9 | 89 | Small GTPase regulator activity |
| RPL27A | 1.8 | 91 | Structural constituent of ribosome |
| TRPM3 | 1.7 | 92 | Calcium ion transport |
| DCAMKL1 | 5.8 | 93 | Cell differentiation |
| KCNIP4 | 1.7 | 94 | Calcium ion binding |
| KCNC4 | 3.8 | 95 | Cation transport |
| IGSF10 | 1.9 | 97 | Vascular endothelial growth factor receptor activity |
| GSTZ1 | 1.8 | 98 | Tyrosine catabolism |
| ZNF367 | 2.1 | 99 | Nucleic acid binding |
| PON1 | 5.8 | 100 | Aryldialkylphosphatase activity |
| HSPB6 | 3.0 | 101 | Response to unfolded protein |