Table 2.
Associations of FTO rs9939609 and rs8050136 genotypes with BMI and waist circumference as continuous traits
| Groups | FTO rs9939609 | ||||
|---|---|---|---|---|---|
| BMI (mean ± s.d.) (kg/m2) | Linear effect on BMIa | ||||
| Genotype | |||||
| T/T | T/A | A/A | β Coefficient (s.e.) | P values | |
| White | 29.0 ± 6.52 (n = 672) | 29.7 ± 6.92 (n = 826) | 30.0 ± 6.77 (n = 339) | 0.53 (0.22) | 0.01 |
| Black | 30.6 ± 6.56 (n = 343) | 31.2 ± 7.42 (n = 504) | 30.9 ± 7.21 (n = 245) | 0.19 (0.29) | 0.52 |
| Hispanic | 28.3 ± 4.92 (n = 208) | 29.3 ± 5.94 (n = 159) | 31.2 ± 8.12 (n = 42) | 1.25 (0.42) | 0.003 |
| Asian/Pacific Islander | 24.9 ± 4.68 (n = 163) | 24.1 ± 4.17 (n = 66) | 25.6 ± 3.35 (n = 10) | −0.44 (0.52) | 0.40 |
| All groups combinedb | 28.8 ± 6.33 (n = 1,386) | 29.9 ± 7.05 (n = 1,555) | 30.3 ± 7.02 (n = 636) | 0.45 (0.15) | 0.004 |
| Groups | Waist circumference (mean ± s.d.) (cm) | Linear effect on waist circumferencea | |||
|---|---|---|---|---|---|
| Genotype | |||||
| T/T | T/A | A/A | β Coefficient (s.e.) | P values | |
| White | 89.8 ± 15.6 (n = 676) | 91.9 ± 16.5 (n = 837) | 92.3 ± 16.2 (n = 339) | 1.39 (0.52) | 0.008 |
| Black | 90.7 ± 13.5 (n = 348) | 91.1 ± 14.9 (n = 509) | 91.2 ± 15.5 (n = 249) | 0.23 (0.60) | 0.70 |
| Hispanic | 85.9 ± 13.8 (n = 212) | 88.1 ± 13.5 (n = 160) | 91.7 ± 14.9 (n = 42) | 2.57 (1.02) | 0.01 |
| Asian/Pacific Islander | 78.4 ± 11.3 (n = 164) | 77.5 ± 11.2 (n = 66) | 78.9 ± 6.21 (n = 10) | −0.70 (1.29) | 0.59 |
| All groups combinedb | 88.1 ± 14.9 (n = 1,400) | 90.6 ± 15.8 (n = 1,572) | 91.6 ± 15.8 (n = 640) | 0.97 (0.35) | 0.006 |
| Groups | FTO rs8050136 | ||||
|---|---|---|---|---|---|
| BMI (mean ± s.d.) (kg/m2) | Linear effect on BMIa | ||||
| Genotype | |||||
| C/C | C/A | A/A | β Coefficient (s.e.) | P values | |
| White | 29.0 ± 6.52 (n = 666) | 29.7 ± 6.87 (n = 833) | 29.9 ± 6.87 (n = 332) | 0.49 (0.22) | 0.02 |
| Black | 31.0 ± 6.94 (n = 380) | 30.8 ± 7.17 (n = 506) | 31.3 ± 7.30 (n = 205) | 0.09 (0.30) | 0.76 |
| Hispanic | 28.3 ± 4.97 (n = 216) | 29.4 ± 5.92 (n = 152) | 30.6 ± 8.27 (n = 42) | 1.12 (0.42) | 0.009 |
| Asian/Pacific Islander | 24.8 ± 4.72 (n = 161) | 24.4 ± 4.19 (n = 64) | 25.3 ± 3.30 (n = 12) | −0.21 (0.51) | 0.69 |
| All groups combinedb | 28.9 ± 6.49 (n = 1,423) | 29.8 ± 6.90 (n = 1,555) | 30.4 ± 7.13 (n = 591) | 0.43 (0.11) | 0.0002 |
| Groups | Waist circumference (Mean ± s.d.) (cm) | Linear effect on waist circumferencea | |||
|---|---|---|---|---|---|
| Genotype | |||||
| C/C | C/A | A/A | β Coefficient (s.e.) | P values | |
| White | 89.9 ± 15.3 (n = 671) | 91.8 ± 16.6 (n = 843) | 92.1 ± 16.4 (n = 332) | 1.24 (0.52) | 0.02 |
| Black | 91.3 ± 13.8 (n = 386) | 90.4 ± 14.8 (n = 512) | 91.9 ± 15.9 (n = 207) | 0.10 (0.62) | 0.87 |
| Hispanic | 86.0 ± 13.7 (n = 220) | 88.5 ± 13.5 (n = 153) | 89.8 ± 15.8 (n = 42) | 2.06 (1.02) | 0.04 |
| Asian/Pacific Islander | 78.4 ± 11.4 (n = 162) | 77.8 ± 11.1 (n = 64) | 77.8 ± 7.55 (n = 12) | −0.75 (1.27) | 0.56 |
| All groups combinedb | 88.4 ± 14.8 (n = 1,439) | 90.5 ± 15.8 (n = 1,572) | 91.6 ± 16.1 (n = 593) | 0.81 (0.36) | 0.02 |
Results in boldface were statistically significant (P < 0.05).
a
Linear regression models were adjusted for matching factors (age, clinical center, and time of blood draw).
b
In all groups combined, crude mean ± s.d. were shown for each genotype and weighted mean linear coefficients (s.e.) for linear effects.