Table 3.
OR (95% CI) for the associations between two FTO SNPs and risk of being overweight and/or obese as compared to being normal weight (BMI < 25 kg/m2)
| Ethnic groups | Pooled estimatesa | ||||
|---|---|---|---|---|---|
| White | Black | Hispanic | Asian/Pacific Islander | ||
| rs9939609b | |||||
| BMI ≥ 25 kg/m2 | |||||
| Recessive model: | 1.32 (1.00–1.73) | 0.84 (0.59–1.20) | 1.14 (0.54–2.43) | 2.17 (0.58–8.06) | 1.13 (0.83–1.54) |
| TT+TA vs. AA | P = 0.05 | P = 0.33 | P = 0.73 | P = 0.25 | P = 0.45 |
| Dominant model: | 1.23 (1.00–1.52) | 0.90 (0.64–1.26) | 0.94 (0.60–1.47) | 0.58 (0.33–1.04) | 0.95 (0.71–1.26) |
| TT vs. TA+AA | P = 0.05 | P = 0.54 | P = 0.77 | P = 0.07 | P = 0.71 |
| Additive model: | 1.19 (1.03–1.37) | 0.90 (0.73–1.12) | 0.99 (0.71–1.38) | 0.76 (0.47–1.24) | 1.00 (0.83–1.21) |
| TT vs. TA vs. AA | P = 0.02 | P = 0.35 | P = 0.95 | P = 0.27 | P = 1.00 |
| BMI ≥ 30 kg/m2 | |||||
| Recessive model: | 1.30 (0.96–1.75) | 0.90 (0.61–1.32) | 1.67 (0.74–3.75) | 1.43 (0.15–13.8) | 1.17 (0.93–1.47) |
| TT+TA vs. AA | P = 0.09 | P = 0.58 | P = 0.22 | P = 0.76 | P = 0.18 |
| Dominant model: | 1.32 (1.04–1.67) | 0.95 (0.67–1.37) | 1.28 (0.76–2.14) | 0.57 (0.21–1.56) | 1.13 (0.88–1.46) |
| TT vs. TA+AA | P = 0.02 | P = 0.80 | P = 0.35 | P = 0.28 | P = 0.33 |
| Additive model: | 1.22 (1.04–1.44) | 0.95 (0.76–1.18) | 1.28 (0.88–1.87) | 0.68 (0.28–1.65) | 1.09 (0.88–1.33) |
| TT vs. TA vs. AA | P = 0.01 | P = 0.63 | P = 0.20 | P = 0.39 | P = 0.44 |
| BMI ≥ 35 kg/m2c | |||||
| Recessive model: | 1.42 (0.99–2.03) | 0.89 (0.57–1.40) | 2.30 (0.88–6.06) | — | 1.28 (0.82–1.98) |
| TT+TA vs. AA | P = 0.06 | P = 0.62 | P = 0.09 | P = 0.27 | |
| Dominant model: | 1.61 (1.20–2.16) | 1.18 (0.77–1.80) | 1.34 (0.68–2.61) | 0.21 (0.02–2.09) | 1.44 (1.15–1.81) |
| TT vs. TA+AA | P = 0.002 | P = 0.45 | P = 0.40 | P = 0.18 | P = 0.002 |
| Additive model: | 1.37 (1.13–1.67) | 1.03 (0.79–1.34) | 1.42 (0.88–2.30) | 0.23 (0.03–1.94) | 1.24 (1.01–1.53) |
| TT vs. TA vs. AA | P = 0.002 | P = 0.86 | P = 0.15 | P = 0.18 | P = 0.04 |
| rs8050136b | |||||
| BMI ≥ 25 kg/m2 | |||||
| Recessive model: | 1.25 (0.95–1.65) | 1.02 (0.69–1.51) | 1.00 (0.48–2.07) | 1.42 (0.43–4.63) | 1.16 (0.94–1.44) |
| CC+CA vs. AA | P = 0.11 | P = 0.93 | P = 0.99 | P = 0.56 | P = 0.17 |
| Dominant model: | 1.15 (0.93–1.41) | 0.86 (0.62–1.19) | 0.96 (0.61–1.51) | 0.69 (0.39–1.23) | 0.98 (0.80–1.20) |
| CC vs. CA+AA | P = 0.21 | P = 0.35 | P = 0.87 | P = 0.2059 | P = 0.81 |
| Additive model: | 1.13 (0.98–1.31) | 0.94 (0.76–1.16) | 0.98 (0.70–1.36) | 0.96 (0.75–1.23) | 1.04 (0.94–1.15) |
| CC vs. CA vs. AA | P = 0.09 | P = 0.56 | P = 0.90 | P = 0.42 | P = 0.47 |
| BMI ≥ 30 kg/m2 | |||||
| Recessive model: | 1.28 (0.95–1.72) | 1.17 (0.77–1.78) | 1.28 (0.57–2.88) | 1.08 (0.12–9.72) | 1.24 (0.99–1.57) |
| CC+CA vs. AA | P = 0.11 | P = 0.46 | P = 0.55 | P = 0.95 | P = 0.06 |
| Dominant model: | 1.26 (0.99–1.59) | 0.86 (0.61–1.23) | 1.31 (0.78–2.18) | 0.62 (0.23–1.71) | 1.08 (0.83–1.41) |
| CC vs. CA+AA | P = 0.06 | P = 0.41 | P = 0.31 | P = 0.36 | P = 0.57 |
| Additive model: | 1.19 (1.02–1.40) | 0.99 (0.79–1.24) | 1.22 (0.84–1.78) | 0.72 (0.30–1.70) | 1.12 (0.99–1.27) |
| CC vs. CA vs. AA | P = 0.03 | P = 0.90 | P = 0.30 | P = 0.45 | P = 0.07 |
| BMI ≥ 35 kg/m2c | |||||
| Recessive model: | 1.37 (0.96–1.96) | 1.12 (0.69–1.81) | 2.01 (0.78–5.18) | — | 1.33 (1.01–1.74) |
| CC+CA vs. AA | P = 0.08 | P = 0.64 | P = 0.15 | P = 0.04 | |
| Dominant model: | 1.17 (1.04–1.31) | 0.89 (0.59–1.34) | 1.38 (0.71–2.68) | 0.24 (0.03–2.41) | 1.15 (1.03–1.29) |
| CC vs. CA+AA | P = 0.007 | P = 0.57 | P = 0.35 | P = 0.23 | P = 0.01 |
| Additive model: | 1.32 (1.09–1.61) | 0.99 (0.76–1.29) | 1.39 (0.87–2.22) | 0.26 (0.03–2.16) | 1.20 (0.97–1.48) |
| CC vs. CA vs. AA | P = 0.006 | P = 0.91 | P = 0.17 | P = 0.21 | P = 0.09 |
Results in boldface were statistically significant (P < 0.05).
CI, confidence interval; OR, odds ratio; SNPs, single-nucleotide polymorphisms.
a
Random-effect meta-analysis to estimate the pooled RR estimates for all case–control samples.
b
Unconditional logistic regression adjusted for matching factors including age, clinical center, and time of blood draw.
c
Pooled estimates for risk of having a BMI ≥35 kg/m2 did not include the unstable estimates for Asian/Pacific Islander group due to sparse sample numbers.