Table 4.
OR (95% CI) for the associations of two FTO SNPs with risk of diabetes mellitus
| Ethnic groups | Pooled estimatesa |
||||
|---|---|---|---|---|---|
| White | Black | Hispanic | Asian/Pacific Islander | ||
| rs9939609 | |||||
| Matching-adjusted modelb | |||||
| Recessive model: TT+TA vs. AA | 1.14 (0.89–1.44) | 1.20 (0.89–1.63) | 0.59 (0.27–1.29) | 1.33 (0.38–4.73) | 1.12 (0.94–1.35) |
| Dominant model: TT vs. TA+AA | 1.18 (0.97–1.43) | 0.99 (0.75–1.32) | 0.83 (0.53–1.28) | 1.23 (0.67–2.23) | 1.09 (0.94–1.26) |
| Additive model: TT vs. TA vs. AA | 1.11 (0.98–1.27) | 1.06 (0.89–1.28) | 0.82 (0.59–1.13) | 1.20 (0.73–1.96) | 1.07 (0.96–1.18) |
| Multivariate-adjusted modelc | |||||
| Recessive model: TT+TA vs. AA | 1.12 (0.87–1.45) | 1.17 (0.84–1.61) | 0.36 (0.13–0.96) | 2.12 (0.54–8.23) | 1.06 (0.75–1.49) |
| Dominant model: TT vs. TA+AA | 1.09 (0.88–1.35) | 0.98 (0.72–1.33) | 0.77 (0.47–1.26) | 1.56 (0.81–3.02) | 1.04 (0.88–1.24) |
| Additive model: TT vs. TA vs. AA | 1.07 (0.93–1.23) | 1.05 (0.86–1.27) | 0.72 (0.49–1.05) | 1.53 (0.88–2.66) | 1.03 (0.87–1.23) |
| rs8050136 | |||||
| Matching-adjusted modelb | |||||
| Recessive model: CC+CA vs. AA | 1.09 (0.86–1.39) | 1.12 (0.81–1.56) | 0.67 (0.31–1.41) | 1.39 (0.41–4.66) | 1.07 (0.89–1.29) |
| Dominant model: CC vs. CA+AA | 1.14 (0.94–1.39) | 0.89 (0.68–1.16) | 0.89 (0.58–1.36) | 1.00 (0.56–1.80) | 1.02 (0.89–1.18) |
| Additive model: CC vs. CA vs. AA | 1.09 (0.95–1.24) | 0.98 (0.82–1.18) | 0.87 (0.63–1.19) | 1.05 (0.65–1.69) | 1.03 (0.93–1.14) |
| Multivariate-adjusted modelc | |||||
| Recessive model: CC+CA vs. AA | 1.06 (0.82–1.37) | 1.15 (0.81–1.63) | 0.49 (0.21–1.17) | 1.93 (0.53–7.04) | 1.04 (0.79–1.37) |
| Dominant model: CC vs. CA+AA | 1.07 (0.87–1.33) | 0.88 (0.66–1.17) | 0.89 (0.55–1.44) | 1.17 (0.62–2.19) | 1.00 (0.85–1.16) |
| Additive model: CC vs. CA vs. AA | 1.05 (0.91–1.21) | 0.98 (0.81–1.19) | 0.82 (0.57–1.17) | 1.22 (0.73–2.04) | 1.01 (0.91–1.13) |
CI, confidence interval; OR, odds ratio; SNPs, single-nucleotide polymorphisms.
a
Random-effect meta-analysis to estimate the pooled OR estimates for all case–control samples.
b
Conditional logistic regression adjusted for matching factors including age, clinical center, and time of blood draw; all the P values are >0.05.
c
Multivarite-adjusted model additionally adjusted for cigarette smoking, alcohol intake, postmenopausal hormone use, and exercise; all the P values are >0.05.