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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Cancer Cell. 2008 Jun;13(6):519–528. doi: 10.1016/j.ccr.2008.04.016

Figure 1. Meta COPA identifies SPINK1 as a mutually exclusive outlier with ERG and ETV1 in prostate cancer.

Figure 1

Meta-COPA analysis of 7 prostate cancer gene expression profiling datasets in Oncomine. The expression of SPINK1 and scatter plots of ERG vs. SPINK1 and ETV1 vs. SPINK1 expression are shown from two studies (Glinsky et al., 2004; Yu et al., 2004) where SPINK1 ranked as a top 100 COPA outlier. A. The expression of SPINK1, in normalized expression units (non-median centered), for all profiled samples including benign prostate tissue (blue) and clinically localized prostate cancer (PCa, red), as well as Gleason pattern 6, 7, 8 or 9 prostate cancer (magenta, orange, light blue and purple, respectively) are shown. B–C. Scatter plots are shown for B) ERG vs. SPINK1 and C) ETV1 vs. SPINK1 for all samples in both studies. Outlier-expression is delineated by the dashed gray lines (See Methods). See Figure S2 for SPINK1 outlier expression in additional prostate cancer profiling studies.

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