Skip to main content
. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Cancer Cell. 2008 Jun;13(6):519–528. doi: 10.1016/j.ccr.2008.04.016

Figure 2. Confirmation of SPINK1 outlier-expression exclusively in ETS negative prostate cancers.

Figure 2

SPINK1 protein expression was evaluated in two cohorts (University of Michigan (UM) and Swedish Watchful Waiting (SWW)) using immunohistochemsitry (IHC) on tissue microarrays that have previously been evaluated for TMRPSS2-ERG status by fluorescence in situ hybridization (FISH). A. Representative SPINK1 positive and negative cores are shown, along with cells from the same cores negative and positive for TMRPSS2-ERG rearrangement by FISH. A TMRPSS2-ERG rearrangement through intrachromosomal deletion is indicated by loss of one 5’ (green) ERG signal. B. Contingency tables for SPINK1 expression and TMRPSS2-ERG status and p-values for Fisher’s exact tests for both cohorts are indicated.

HHS Vulnerability Disclosure