Figure 4. SPINK1 outlier expression can be detected non-invasively in urine.
Non-invasive detection of SPINK1 outlier-expression in men with TMRPSS2-ERG negative prostate cancer. Total RNA was isolated from the urine of 148 men with prostate cancer and assessed for TMRPSS2-ERG and SPINK1 expression by quantitative PCR. Samples above the dashed red line show SPINK1 outlier expression (See Methods).