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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cancer Res. 2009 Jul 21;69(15):6256–6264. doi: 10.1158/0008-5472.CAN-08-4516

Figure 5. APCs from prostate tumors have an increased stimulatory ability after TcR-II cell transfer.

Figure 5

APCs were isolated from WT or TRAMP prostates at the indicated time after transfer of TcR cells. A, Phenotype of isolated APCs day 20 after T cell transfer (similar results were observed on days 5 and 10 after transfer). B,C, APCs isolated from non-transferred or mice receiving single transfers of TcR-I or TcR-II cells were analyzed for the ability to stimulate naïve CD8+ T cell proliferation in vitro. Data is expressed as mean ± SEM (**P = 0.0017, B) and is representative of at least 3 separate experiments. D, Mice were treated with FTY720 prior to TcR cell transfer and APCs were isolated 7 days after transfer of TcR cells and analyzed for the ability to stimulate naïve CD8+ T cell proliferation in vitro. Data is expressed as average CPM ± SEM (**P < 0.01).