Table 2.

Unadjusted and adjusted HRs for secondary outcomes with adjusted HRs for incidence of cancer stratified by maximum prescribed dose and duration of follow-up with comparators as the reference category

	n (%)	Unadjusted	Adjusted*
Incidence of bowel cancer
Comparators	76 (1.9)	1.00	1.00
Users	40 (1.0)	0.41 (0.28–0.61)	0.60 (0.38–0.94)
Incidence of lung cancer
Comparators	58 (1.4)	1.00	1.00
Users	35 (0.9)	0.49 (0.32–0.74)	0.70 (0.43–1.15)
Incidence of breast cancer in women
Comparators	41 (2.2)	1.00	1.00
Users	24 (1.3)	0.44 (0.26–0.73)	0.60 (0.32–1.10)
Overall mortality
Comparators	1,422 (34.8)	1.00	1.00
Users	609 (14.9)	0.32 (0.29–0.35)	0.42 (0.38–0.47)
Mortality from cancer
Comparators	248 (6.1)	1.00	1.00
Users	123 (3.0)	0.48 (0.39–0.60)	0.63 (0.49–0.81)
Incidence of cancer	<2 years follow-up*	2–4 years follow-up*	>4 years follow-up*
Maximum prescribed dose during follow-up (n)
Low (1,017)	3.15 (1.92–5.18)	0.99 (0.44–2.25)	0.16 (0.06–0.44)
Medium (2,090)	1.94 (1.20–3.13)	0.51 (0.31–0.82)	0.40 (0.27–0.60)
High (978)	2.76 (0.56–13.45)	0.28 (0.12–0.70)	0.15 (0.09–0.25)

Data are HR (95% CI) unless otherwise indicated.

*Adjusted for age, sex, smoking, deprivation, BMI, A1C, insulin use, and sulphonylurea use.