Table 3.

Group differences from TOI analysis of regional radial diffusivity (D_ra) values as a function of diagnosis; the synopsis of the findings from voxel-wise analysis

Region	TOI analysis
	Dra (mean ± SD)			P-values			Voxel-wise analysis
	CN	FTD	AD	FTD>CN	AD>CN	FTD>ADa	FTD>CN	AD>CN	FTD>ADb
a.CC	0.70 ± 0.09	0.93 ± 0.21	0.77 ± 0.10	0.0002	0.03	0.01	S	S	S
p.CC	0.57 ± 0.06	0.64 ± 0.10	0.65 ± 0.09	0.01	0.004	NS	S	S	NS
L.a.Cg	0.55 ± 0.05	0.67 ± 0.07	0.61 ± 0.07	<0.0001	0.004	0.02	S	S	S
R.a.Cg	0.61 ± 0.04	0.70 ± 0.06	0.65± 0.08	<0.0001	NS	0.03	S	S	S
L.p.Cg	0.55 ± 0.05	0.59 ± 0.05	0.60 ± 0.05	0.008	0.002	NS	S	S	NS
R.p.Cg	0.56 ± 0.04	0.61 ± 0.05	0.60 ± 0.05	0.01	0.003	NS	S	S	NS
L.d.Cg	0.66 ± 0.06	0.81 ± 0.15	0.81 ± 0.12	0.001	<0.0001	NS	S	S	S
R.d.Cg	0.62 ± 0.06	0.74 ± 0.14	0.78 ± 0.16	0.003	0.0003	NS	S	S	NS
L.Unc	0.69 ± 0.04	0.84 ± 0.12	0.77 ± 0.07	<0.0001	<0.0001	0.01	S	S	S
R.Unc	0.68 ± 0.06	0.89 ± 0.21	0.75 ± 0.09	<0.0001	0.01	0.002	S	S	S
L.CST	0.61 ±0.05	0.63 ± 0.07	0.60 ± 0.07	NS	NS	NS	NS	NS	NS
R.CST	0.49 ± 0.03	0.54 ± 0.09	0.49 ± 0.04	0.01	NS	0.02	S	NS	S

a No region showed significant increased D_ra in Alzheimer's disease when compared to FTD (AD>FTD).

b No region showed significant increased D_ra in Alzheimer's disease when compared to FTD (AD>FTD).

a.CC/p.CC = anterior/posterior corpus callosum; L.a.Cg/R.a.Cg = Left/Right anterior cingulum; L.p.Cg/R.p.Cg = Left/Right posterior cingulum; L.d.Cg/R.d.Cg = Left/Right descending cingulum; L.Unc/R.Unc = Left/Right uncinate fasciculus; L.CST/R.CST = Left/Right corticospinal tract.