Figure 3.

In vivo metabolic phenotype of Gpr39-deficient mice. A, OGTTs performed in female [Gpr39(+/+), n = 12, and Gpr39(−/−), n = 10] and male mice [Gpr39(+/+), n = 5 and Gpr39(−/−), n = 5], respectively, at 11–12 wk of age; glucose was measured in tail blood. For female mice significantly higher blood glucose was observed in Gpr39(−/−) (in black) compared with WT (in white) controls at time point 20 and 30 min after glucose administration with P = 0.009 and 0.011, respectively. Area under the curve (AUC) is shown as an insert (***, P = 0.001). B, IVGTTs performed in female [Gpr39(+/+), n = 6, and Gpr39(−/−), n = 4] and male mice [Gpr39(+/+), n = 5, and Gpr39(−/−), n = 5], respectively, at 17–18 wk of age; glucose was measured in venous tail blood. Area under the curve for the first 20 min is shown as an insert (*, P = 0.03; ***, P = 0.0003). C, Increment in plasma insulin during the first 15 min after an oral glucose load (∼OGTT) for female (left panel) and male (right panel) Gpr39(+/+) mice (black column, n = 4–6) and in Gpr39(−/−) animals (white column, n = 5–6). *, P = 0.04.