Table 1.
General phenotype of GPR39-deficient mice
|
Gpr39(+/+)
|
Gpr39(+/−)
|
Gpr39(−/−)
|
||||
|---|---|---|---|---|---|---|
| Mean ± sem | n | Mean ± sem | n | Mean ± sem | n | |
| Body weight (g) | 24.5 ± 1.3 | 10 | 26.3 ± 1.1 | 10 | 26,7 ± 1,3 | 11 |
| FFAs (mg/dl) | 27 ± 5 | 11 | 23 ± 4 | 11 | 29 ± 5 | 9 |
| TGs (mg/dl) | 56 ± 8 | 11 | 58 ± 12 | 11 | 69 ± 14 | 9 |
| Glucose (mm) | 6.6 ± 0.4 | 25 | 6.5 ± 0.3 | 24 | 5.6 ± 0.3 | 24 |
| Insulin (ng/ml) | 0.46 ± 0.05 | 18 | 0.49 ± 0.07 | 18 | 0.45 ± 0.05 | 14 |
| Glucagon (pm) | 130 ± 3 | 11 | 132 ± 4 | 11 | 117 ± 5a | 9 |
Body weight and plasma measurements of nonesterified FFAs, TGs, glucose, insulin, and glugacon in 16- to 18-h fasted male and female mice at 21–22 wk of age.
a
Significantly lower value in knockout group compared with WT.