Table II.
Comparison of control and irradiated PC3N cell variants
| Cell line and treatment | Median tumor wt [mg] on day 25 (p value)] | % T/C, day 25 | Median time for tumor wt to reach 1300 mg in days (p value) | T-C (days) | Td (days)* | Log10 cell kill total |
|---|---|---|---|---|---|---|
| PC3N-α6-WT | 1353 | – | 24.5 – | – | 5.5 | – |
| PC3N-α6-WT + RT | 489 (p = 0.006) | 36.1 | 45 (0.01) | 20.5 | – | 1.1 |
| PC3N-α6-RR | 953 (p = 0.51) | 26.5 (0.63) | 10.5 | |||
| PC3N-α6-RR + RT | 534 (p = 0.009) | 39.5 | 53 (0.001) | 28.5 | – | 1.6 |
| PC3N-α6-RR + RTt | 534 (p = 0.003) | 56 | 53 (<0.001) | 26.5 | – | 0.8 |
*
Estimated from log-linear plot of data in Table I;
t
PC3N-α6-RR + RT values calculated against PC3N-α6-RR values;
% T/C = (Median Tumor Weight of Treated/Median Tumor Weight of Control) × 100;
T-C is tumor growth delay based upon the median time in days required for the treatment group (T) and the untreated control group (c) tumor to reach 1300 mg;
Td = Tumor doubling in days from log-linear portion of the tumor growth curve for untreated tumors;
Log Cell Kill = T-C/(3.32 × Td).