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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Eur Arch Psychiatry Clin Neurosci. 2009 Mar 3;259(6):316–328. doi: 10.1007/s00406-009-0002-8

Fig. 2.

Fig. 2

Areas of significantly reduced FA (a) and increased MD (b) in depressed BD-I patients compared to euthymic BD-I individuals, with age as covariate. Results at the Z > 2.33 threshold were overlaid on axial brain slices of, respectively, FA and MD maps spatially normalized into an approximation to the Tailarach and Tornoux stereotactic atlas [37]. Foci of reduced FA in left cingulate sub-gyral WM, in the posterior limb of the right internal capsule, right external capsule and also in right parietal WM, besides extensive regions of increased MD involving right ventromedial prefronto-limbic WM, bilateral fronto-limbic-parietal networks, and right temporo-occipital WM were observed in the depressed BD-I subgroup versus euthymic BD-I patients. The numbers associated with each frame represent standard coordinates in the z axis. The left side of the brain is shown on the left side of each section. FA, fractional anisotropy; MD, mean diffusivity; BD-I, bipolar disorder type I. FA, fractional anisotropy; BD-I, bipolar disorder type I; WM, white matter