Table 2.

Regions of significantly reduced FA and increased MD in all BD-I patients (n = 37) compared to healthy controls (n = 26)

Reduced FA	Hemisphere	Talairach and Tournoux coordinates (peak voxel)			Peak Z score	No. of voxels	P
White matter tract/region		x	y	z
External capsule	Right	26	−8	5	3.42	79	< 0.001
External capsule	Left	−27	7	19	3.33	128	< 0.001
Superior and inferior longitudinal fasciculi	Right	36	−55	0	3.17	50	0.001
Increased MD	Hemisphere	Talairach and Tournoux coordinates (peak voxel)			Peak Z score	No. of voxels	P
White matter tract/region		x	y	z
Superior and inferior longitudinal fasciculi	Right	41	−65	2	4.21	414	< 0.001

FA, fractional anisotropy; MD, mean diffusivity; BD-I, bipolar I disorder