Figure 3.
Immunohistochemical staining of Topoisomerase 2 alpha, Aurora kinase B and Stathmin-1 in the lateral prostate lobe of young and aged rats. A, Strong nuclear staining of Topo2a at 4 months of age; B, Absence of Topo2a immunostaining at 24 months of age; C, Nuclear Aurkb immunostaining at 4 months of age; D, Absence of Aurkb immunostaining at 24 months of age; E, Cytoplasmic immunostaining of Stmn1 at 4 months of age; and F, Decreased immunostaining of Stmn1 at 24 months of age. Arrowheads indicate stromal cells with positive immunostaining. Tissues were counterstained with hematoxylin. Magnification in panels A-F, 400X; inset in A and C, 800 X.