Figure 5.
Immunohistochemical detection and co-localization of Topo2a, Aurkb, and Stmn1 expression in focal regions of epithelial hyperplasia marked by Ki67 immunopositive cells in the lateral and dorsal lobes of 24 month old rats. Serial sections through a focal lesion in the lateral lobe shows immunostaining for Ki-67 (A), Topo2a (B), Aurkb (C), and Stmn1 (D). Similarly, serial sections through a focal lesion in the dorsal lobe shows immunostaining for Ki-67 (E), Topo2a (F), AurkB (G) and to a lesser extent, Stmn1 (H). Magnification, 400X.