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. 2008 Apr 1;22(7):832–853. doi: 10.1101/gad.1652708

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Figure 4. — Alterations in histone methylation patterns in HGPS fibroblasts. Normal and HGPS fibroblasts from female donors were double-labeled with antibodies against lamins A/C (red) and against trimethylation of either Lys 9 in histone H3 (H3K9me3; A,B), Lys 27 in histone H3 (H3K27me3; C,D), or Lys 20 in histone H4 (H4K20me3; E,F) (all green). Note the decrease of H3K9me3 (B) and H3K27me3 (D) and the increase of H4K20me3 (F) in the lobulated HGPS nuclei compared with normal nuclei (A,C,E). The decrease in H3K27me3 is best observed at the inactive X chromosome, which is normally enriched in this histone modification (see arrowhead in C). Bars, 10 μM.