Figure 1.
Relationship Among Cognitive Impairment Entities (AAMI = Age-Associated Memory Impairment, BSF = Benign Senescent Forgetfulness, CIND = Cognitive Impairment No Dementia, AACD = Aging-Associated Cognitive Decline, MCI = Mild Cognitive Impairment, a-MCI = amnestic MCI, MSF = Malignant Senescent Forgetfulness). AAMI/BSF have indistinct borders with Normal Aging and this is reflected in the porous outline of the circle separating AAMI/BSF from Normal Aging. The large size of the circles containing these non-clinical entities reflects the large proportion of the general population contained within. The circles representing CIND/AACD and MCI/MSF are smaller reflecting the relative rarity of these clinical disorders compared to the general population of basically cognitively healthy older adults. The enclosure of MCI and a-MCI/MSF within CIND/AACD indicates that these are subsets within CIND/AACD. The expansion of the MCI concept 27 to include non-amnestic and multi-domain forms is represented by the outward pointing arrows extending the disorder to be equivalent in scope to CIND.