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. 2000 Mar 25;320(7238):840–841. doi: 10.1136/bmj.320.7238.840

Table.

Odds ratios (95% confidence interval) for all cause mortality and disability by birthweight and sex

Age (years) No of deaths/ with disability* Birthweight (g)
P value for trend
<2500 (n=743) 2500-3249 (n=3503) 3250-3749 (n=5657) 3750-4249 (n=4668) >4249 (n=2111)
Mortality
Males:
 <1 46 8.41 (2.03 to 34.7) 4.51 (1.27 to 34.8) 2.27 (0.63 to 8.18) 1.58 (0.42 to 6.01) 1.00 <0.001
 1-15 68 1.15 (0.31 to 4.25) 1.07 (0.47 to 2.43) 0.95 (0.45 to 2.02) 1.01 (0.48 to 2.12) 1.00 0.71
 16-38 143 0.45 (0.13 to 1.51) 1.23 (0.74 to 2.04) 0.61 (0.36 to 1.03) 0.77 (0.47 to 1.26) 1.00 0.94
Females:
 <1 36 2.01 (0.27 to 14.9) 2.94 (0.65 to 13.4) 1.37 (0.29 to 6.44) 1.62 (0.33 to 7.89) 1.00 0.12
 1-15 51 2.02 (0.39 to 10.4) 2.11 (0.59 to 7.50) 1.18 (0.33 to 4.27) 2.31 (0.66 to 8.09) 1.00 0.52
 16-38 79 1.45 (0.45 to 4.70) 1.09 (0.44 to 2.66) 1.09 (0.47 to 2.56) 1.22 (0.51 to 2.94) 1.00 0.91
Disability*
Males:
 7 403 (7005) 1.78 (0.94 to 3.37) 1.42 (1.00 to 2.01) 1.24 (0.90 to 1.70) 0.96 (0.69 to 1.34) 1.00 0.02
 16 541 (5746) 1.51 (0.81 to 2.80) 1.79 (1.32 to 2.42) 1.18 (0.88 to 1.57) 1.03 (0.76 to 1.38) 1.00 <0.001
 23 197 (5017) 3.65 (1.77 to 7.49) 1.33 (0.80 to 2.22) 1.03 (0.65 to 1.64) 1.20 (0.76 to 1.89) 1.00 0.09
 33 212 (4387) 2.32 (0.97 to 5.55) 1.19 (0.72 to 1.98) 1.30 (0.84 to 2.01) 1.14 (0.73 to 1.78) 1.00 0.15
Females:
 7 274 (6672) 2.35 (1.19 to 4.62) 1.44 (0.88 to 2.37) 1.32 (0.82 to 2.13) 1.07 (0.64 to 1.77) 1.00 0.001
 16 392 (5545) 0.71 (0.35 to 1.42) 0.82 (0.56 to 1.19) 0.90 (0.63 to 1.27) 0.74 (0.51 to 1.08) 1.00 0.41
 23 158 (5267) 2.24 (0.93 to 5.37) 1.49 (0.80 to 2.75) 1.01 (0.55 to 1.87) 1.00 (0.52 to 1.89) 1.00 0.02
 33 242 (4741) 2.06 (0.94 to 4.51) 1.37 (0.80 to 2.36) 1.28 (0.76 to 2.14) 1.55 (0.91 to 2.63) 1.00 0.17
*

Newly identified cases from school doctor and health visitor assessments of disabling “abnormal conditions” ages 7-16, and from individual reports of a limiting longstanding illness ages 23 and 33; the denominator is all those with data minus subjects with disability at any previous age. 

Trend tests were performed with continuous measures of birthweight. The P values show the significance of linear trend except for disability at 7 for males, which has a quadratic trend.