Scheme 5.
Completion of the rocaglamide skeleton
Reagents and conditions: (a) DDQ (4 equiv.), DCM, 71% (b) KHMDS, PhNTf2, THF, 0°C, 83% (c) Pd(PPh3)4, CO, MeOH, Hünig's base, THF, 65°C, 79%.
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