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Network regulating PER protein phosphorylation and stability. All of the protein products shown alter circadian rhythms and alter PER phosphorylation and/or stability when mutated in flies. The connectors indicate additional support for the network coming from diverse lines of evidence. See the text for details. The study by Chiu et al. (2008) identified sites on PER phosphorylated by DBT and recognized by Slimb (green lines).
