Table 2. Results of time-kill study of two isolates of pandrug-resistant Acinetobacter baumannii (PDRAB).
MIC (µg/mL)a |
||
---|---|---|
Isolate I |
Isolate II |
|
Antibiotic | (clone 5) | (clone 6) |
Alone | ||
Imipenem | 32 | 32 |
Amikacin | 128 | 64 |
Ciprofloxacin | 128 | 2 |
Ampicillin-sulbactam | 128 | 32 |
Combination | ||
Imipenem + amikacin | 16/64 | 2/4 |
Imipenem + ciprofloxacin | 32/128 | 4/0.25 |
Imipenem + ampicillin-sulbactam | 16/64 | 8/8 |
Ciprofloxacin + ampicillin-sulbactam | 128/128 | 1/16 |
aValues are the lowest concentrations (µg/mL) of each agent in combination that yielded synergy.