Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overall reaction scheme of Pf-Sir2 catalyzed reactions. Top scheme depicts solvolytic chemistry in the absence of peptide which gives inversion of stereochemistry (reaction a). Bottom scheme depicts acetyllysine dependent chemistries which occur via the imidate including base exchange (reaction b), solvolysis from the imidate (reaction c) and deacetylation (reaction d)
