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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Neuron. 2008 Dec 26;60(6):1068–1081. doi: 10.1016/j.neuron.2008.10.046

Figure 4.

Figure 4

Odor-evoked activity in the epithelium and olfactory bulb of M71 transgenic mice. (A-C) Representative electro-olfactogram (EOG) recordings from control (A) and M71 transgenic (B) mice in response to either a cocktail of odorants (blue) or to acetophenone (red). (C) Acetophenone sensitivity in M71 transgenic and control mice, expressed as the ratio of integrated EOG responses to acetophenone and to an odorant cocktail. (D-R) Two-photon imaging of odor-evoked activity in the olfactory bulb in response to 1% ethyl acetate, 1% eugenol and 1% isoamyl acetate in control (D-F) and M71 transgenic animals (I-K). Pseudo-colored heat maps show mean percent change in fluorescence (ΔF/F) for each odor. Activity evoked by 1% acetophenone and 10% acetophenone in control (G, H) and M71 transgenic bulbs (L, M). Activity evoked by 1% acetophenone and 10% acetophenone in the presence of the GABAB-receptor antagonist CGP46381 in control (N,O) and M71 transgenic bulbs (P, Q); same image fields as before antagonist application as shown in G-M. Summary table of the fraction of glomeruli responding to each odor in control and M71 transgenic mice.