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Opioid-related ADE rates in perioperative care. 419 Naloxone alerts in 36,533 surgical encounters are either due to intraoperative naloxone (318) or postoperative (101) post anesthesia care unit (PACU) usage. Of the 101 PACU cases, 69 were determined to be ADE's. ADE rates are further subdivided by inpatient and ambulatory subgroups.
