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Major signaling pathways were altered in H-JNK1 HCC tissue. Genes for cell cycle pathway (A) and HIF-1 signaling (B) were up-regulated in H-JNK1 HCC tissue as determined by Ingenuity Pathways Analysis. Genes involved in HNF4A transcription network (C) and for the p450 family members (D) were down-regulated in H-JNK1 HCC tissue.
