Figure 1. Generation of GIT1 KO mice.

A. Strategy to generate GIT1 KO mice by homologous recombination. Exons 2-7 were replaced with the targeting vector containing a neomycin-resistance cassette. B. Analysis of GIT1 and GIT2 transcripts by RT-PCR. C. GIT1 protein expression in different tissues of WT and KO mice.