Table 5.

Regression coefficients in the final mixed-effects regression models for the depressed mood subscale for selected regions^*

Brain region	Baseline age	Interval	Depressed mood	Baseline age × depressed mood	Depressed mood × interval	Depressed mood × sex
Frontal white matter
Left	−369.2†	−412.4†	84.6	—	−103.8†	2436.1†
Right	−400.9†	−1344.3†	1215.7‡	—	—	—
Left temporal gray matter	−154.8†	−345.5†	4288.6‡	−62.9‡	—	—
Right temporal white matter	−252.5†	−1034.8†	482.1	—	—	—
Cingulate gyrus	−100.9†	−209.9†	2443.8	−43.2‡	—	737.6‡
Orbitofrontal cortex	−3.1	−81.3†	2104.1	−30.6§	—	—

^*Intracranial volume and sex were entered as covariates in all analyses. Intracranial volume was significant in all models (all p < 0.001). The sex effect (smaller volumes in men) was significant for left frontal white matter (p = 0.004) and the cingulate gyrus (p < 0.001). Blanks indicate variables that were dropped from the model by backward elimination.

^†Significance at p < 0.05.

^‡Significance at p < 0.01.

^§p = 0.054.