Table 1.
Characteristics of mutations segregating with diabetes in the linked interval at 8p23
| Family | Origin | Chr | Position* | Substitution | Nondiabetic subjects |
|
|---|---|---|---|---|---|---|
| Whites (n = 672)† | AA (n = 1,154)† | |||||
| F17 | AA | 8 | 11,369,157 | G > A | 0 (0.00) | 0 (0.00) |
| F8 | W | 8 | 11,442,985 | G > A (A71T) | 2 (0.003)‡ | NT |
| F8 | W | 8 | 11,459,364 | T > G | 2 (0.003)‡ | NT |
| F9 | W | 8 | 11,459,531 | G > T | 0 (0.00) | NT |
| F8 | W | 8 | 11,468,050 | C > T | 2 (0.003)‡ | NT |
AA, African-American; W, White; NT, not tested.
*Position according to NCBI Build 36.1.
†Number of chromosomes that were tested.
‡These 3 mutations always occurred together as a haplotype.