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Functional consequences of the CRH −248 C → T SNP. Reporter assay result, comparing promoter activity of −248 C and T constructs at baseline and following treatment with forskolin, forskolin + dexamethasone, and TPA. Constructs were co-transfected with a GFP reporter, and an expression value was obtained by dividing intensity of pDsRed by that for GFP. GFP and dsRed images were merged by overlaying the GFP image with the dsRed image (both at 40% transparency). *, P < 0.05.
