Table 2.

Risk of 10-Year Cumulative Incidence of Age-related Macular Degeneration by the Presence of the Complement Factor H Gene Variant (Y402H rs1061170) in the Blue Mountains Eye Study Population Between 1992–1994 and 2002–2004

Model for Genotype	Early AMD				Late AMD
	No. at Risk	No. of Cases	Relative Risk, Age and Sex Adjusted	95% Confidence Interval	No. at Risk	No. of Cases	Relative Risk, Age and Sex Adjusted	95% Confidence Interval
Additive
TT/CT/CCa	1,705	185	1.55	1.24, 1.94	1,791	47	2.33	1.50, 3.62
Recessive
CT/TT	1,478	149	1.0		1,547	34	1.0
CC	227	36	2.40	1.52, 3.77	244	13	2.75	1.40, 5.39
Dominant
TT	689	53	1.0		711	7	1.0
CT/CC	1,016	132	1.76	1.26, 2.45	1,080	40	3.49	1.54, 7.88

Abbreviation: AMD, age-related macular degeneration.

^aThe referent group is subjects with the TT genotype.