Table 4.
Positive HPV6, 11, and 18 serology and HNSCC risk
| Serology | Controls, n (%) | Pharynx |
Oral |
Larynx |
||||||
| Cases, n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)a | Cases, n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)a | Cases, n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)a | ||
| HPV6 | ||||||||||
| Negative | 472 (86%) | 149 (73%) | 1.0 | 1.0 | 150 (79%) | 1.0 | 1.0 | 76 (82%) | 1.0 | 1.0 |
| Positive | 76 (14%) | 55 (27%) | 2.3 (1.5–3.4) | 1.6 (1.0–2.5) | 39 (21%) | 1.6 (1.1–2.5) | 1.4 (0.9–2.1) | 17 (18%) | 1.4 (0.8–2.5) | 1.1 (0.6–2.0) |
| HPV6b | ||||||||||
| Negative | 472 (86%) | 149 (73%) | 1.0 | 1.0 | 150 (79%) | 1.0 | 1.0 | 76 (82%) | 1.0 | 1.0 |
| Low titer | 43 (8%) | 27 (13%) | 2.0 (1.2–3.3) | 1.5 (0.8–2.6) | 13 (7%) | 1.0 (0.5–1.8) | 0.9 (0.4–1.7) | 9 (10%) | 1.3 (0.6–2.8) | 1.1 (0.5–2.5) |
| High titer | 33 (6%) | 28 (14%) | 2.7 (1.6–4.6) | 1.8 (1.0–3.2) | 26 (14%) | 2.5 (1.4–4.3) | 1.9 (1.1–3.4) | 8 (9%) | 1.5 (0.7–3.4) | 1.0 (0.4–2.3) |
| HPV11 | ||||||||||
| Negative | 517 (94%) | 186 (91%) | 1.0 | 1.0 | 176 (93%) | 1.0 | 1.0 | 88 (95%) | 1.0 | 1.0 |
| Positive | 31 (6%) | 18 (9%) | 1.6 (0.9–3.0) | 0.9 (0.5–1.9) | 13 (7%) | 1.2 (0.6–2.4) | 1.0 (0.5–2.0) | 5 (5%) | 0.9 (0.4–2.5) | 0.7 (0.2–2.0) |
| HPV11b | ||||||||||
| Negative | 517 (94%) | 186 (91%) | 1.0 | 1.0 | 176 (93%) | 1.0 | 1.0 | 88 (95%) | 1.0 | 1.0 |
| Low titer | 16 (3%) | 8 (4%) | 1.4 (0.6–3.3) | 0.8 (0.3–2.2) | 6 (3%) | 1.1 (0.4–2.9) | 0.8 (0.3–2.2) | 2 (2%) | 0.7 (0.2–3.3) | 0.5 (0.1–2.3) |
| High titer | 15 (3%) | 10 (5%) | 1.9 (0.8–4.2) | 1.0 (0.4–2.7) | 7 (4%) | 1.4 (0.6–3.4) | 1.2 (0.5–3.0) | 3 (3%) | 1.2 (0.3–4.1) | 1.0 (0.3–3.7) |
| HPV18 | ||||||||||
| Negative | 505 (92%) | 175 (86%) | 1.0 | 1.0 | 178 (94%) | 1.0 | 1.0 | 86 (92%) | 1.0 | 1.0 |
| Positive | 43 (8%) | 29 (14%) | 1.9 (1.2–3.2) | 1.3 (0.7–2.3) | 11 (6%) | 0.7 (0.4–1.4) | 0.7 (0.3–1.4) | 7 (8%) | 1.0 (0.4–2.2) | 0.8 (0.3–2.0) |
| HPV18b | ||||||||||
| Negative | 505 (92%) | 175 (86%) | 1.0 | 1.0 | 178 (94%) | 1.0 | 1.0 | 86 (92%) | 1.0 | 1.0 |
| Low titer | 22 (4%) | 15 (7%) | 2.0 (1.0–3.9) | 1.5 (0.7–3.4) | 5 (3%) | 0.6 (0.2–1.7) | 0.6 (0.2–1.6) | 3 (3%) | 0.8 (0.2–2.7) | 0.6 (0.2–2.2) |
| High titer | 21 (4%) | 14 (7%) | 1.9 (1.0–3.9) | 1.1 (0.5–2.5) | 6 (3%) | 0.8 (0.3–2.0) | 0.8 (0.3–2.1) | 4 (4%) | 1.1 (0.4–3.3) | 1.1 (0.4–3.5) |
Bold typeface indicates P < 0.05.
a
Cases and controls matched for age and gender; adjusted models controlled for smoking, drinking, and HPV16.
b
Low and high titer categories determined using median positive titer values as cut points (HPV6 = 20, HPV11 = 13, HPV18 = 14.5).