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Estimated pharmacodynamic parameters for Class 4 genes.
| Parameters | Definitions | GR | CA | GA |
|---|---|---|---|---|
| Estimate (CV%) | ||||
| kdgr,GR (h−1) | Loss rate of gene | 0.16 (21.8) | 1.39 (27.6) | 0.13 (12.2) |
| IC50 (fmol/mg protein) | DR(N) for half-maximal inhibition | 162.8 (36.8) | 385.1 (14.9) | 14.92 (56) |
| SF | Scaling factor | 1.09 (40.6) | – | – |
| GRm0,acute | Baseline-Acute | 1.0 (fixed) | 1 (fixed) | 1 (fixed) |
| GRm0,chronic | Baseline-Chronic | 1.26 (8.9) | – | – |
