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Dose-limiting toxicity (DLT) and best response
| Bortezomib (mg/m2/dose) | Cyclophosphamide (mg/m2/dose) | Doxorubicin (mg/m2/dose) | Total no. of patients | DLT | No. of cycles | Best response |
| 1.0 | 750 | 50 | 7 | Grade 4 neutropenia with fever | 34 | 5 CRs, 1 SD, 1 PD |
| 1.3 | 750 | 50 | 3 | None | 13 | 2 SDs, 1 CR |
| 1.6 | 750 | 50 | 3 | None | 8 | 1 CR, 1 CRu, 1 PD |
CR, complete remission; SD, stable disease; PD, progressive disease; CRu, complete remission, undetermined.
