Table 3.
Toxicity profile
| Bortezomib | |||
| 1.0 mg/m2/dose (n = 7) | 1.3 mg/m2/dose (n = 3) | 1.6 mg/m2/dose (n = 3) | |
| Anemia | |||
| Grade 1 | – | 1 | – |
| Grade 2 | 1 | – | – |
| Grade 3 | – | – | – |
| Grade 4 | – | – | – |
| Neutropenia | |||
| Grade 1 | – | 1 | – |
| Grade 2 | – | – | – |
| Grade 3 | 2 | 1 | – |
| Grade 4 | 2 | – | 1 |
| Febrile neutropenia | |||
| Grade 3 | – | – | 1 |
| Grade 4 | 2 | – | – |
| Thrombocytopenia | |||
| Grade 1 | – | – | – |
| Grade 2 | – | – | – |
| Grade 3 | 1 | – | – |
| Grade 4 | – | – | – |
| Sensory neuropathy | |||
| Grade 1 | 2 | 1 | 1 |
| Grade 2 | – | – | – |
| Grade 3 | – | – | – |
| Grade 4 | – | – | – |
| Fatigue | |||
| Grade 1 | 2 | 1 | 1 |
| Grade 2 | 1 | – | 1 |
| Grade 3 | – | – | – |
| Grade 4 | – | – | – |
| Diarrhea | |||
| Grade 1 | – | 1 | – |
| Grade 2 | – | – | – |
| Grade 3 | 1 | – | 1 |
| Grade 4 | – | – | – |
| Anorexia | |||
| Grade 1 | 1 | 1 | 1 |
| Grade 2 | 1 | – | – |
| Grade 3 | – | – | – |
| Grade 4 | – | – | – |
| Nausea | |||
| Grade 1 | 2 | 2 | 1 |
| Grade 2 | 2 | – | 1 |
| Grade 3 | – | – | – |
| Grade 4 | – | – | – |
| Liver function | |||
| Grade 1 | 1 | – | – |
| Grade 2 | 1 | – | – |
| Grade 3 | 1 | – | – |
| Grade 4 | – | – | – |