Table 1.
Age at which the cumulative risk of cancer reaches one per 1000 among individuals without and with affected parents/siblings and difference in diagnosis age compared with individuals with affected parents and siblings
| Cancer site | Without family history |
With affected parents |
With affected siblings |
|||||||
| Age | 95% CI | No.a | Age | 95% CI | ADb | No.a | Age | 95% CI | ADb | |
| Cervix | 34.4 | 33.9, 35.1 | 22 | 30.9 | 29.6, 33.2 | −3.5 | 6 | 30.4 | 25.9, 33.8 | −4.0 |
| Breast | 37.3 | 37.2, 37.5 | 168 | 33.5 | 33.1, 34.0 | −3.8 | 46 | 34.0 | 33.2, 35.1 | −3.3 |
| Ovary | 41.1 | 40.2, 42.1 | 19 | 33.1 | 27.2, 36.9 | −8.0 | ||||
| Melanoma | 41.8 | 41.3, 42.3 | 105 | 31.5 | 30.4, 33.3 | −10.3 | 36 | 32.0 | 29.8, 34.9 | −9.8 |
| Women | 40.5 | 39.9, 41.2 | 61 | 30.8 | 29.3, 32.5 | −9.8 | 23 | 31.0 | 28.7, 33.4 | −9.5 |
| Men | 43.0 | 42.5, 43.6 | 44 | 32.8 | 31.0, 34.7 | −10.3 | 14 | 33.0 | 30.6, 36.6 | −10.0 |
| Nervous system | 44.1 | 43.3, 45.0 | 104 | 33.3 | 29.9, 36.8 | −10.8 | 34 | 29.9 | 23.4, 34.8 | −14.2 |
| Colorectum | 47.4 | 47.0, 47.8 | 211 | 41.3 | 40.3, 42.3 | −6.1 | 23 | 40.8 | 39.3, 42.2 | −6.9 |
| Endometrium | 48.6 | 48.2, 49.0 | 15 | 44.1 | 39.4, 45.8 | −4.5 | ||||
| NHL | 50.8 | 50.1, 51.3 | 54 | 45.3 | 43.3, 49.1 | −5.4 | 11 | 47.1 | 33.7, 50.6 | −3.7 |
| Women | 52.8 | 52.2, 53.5 | 15 | 48.9 | 45.4, 50.9 | −3.9 | 10 | 48.7 | 36.8, 51.3 | −4.8 |
| Men | 49.1 | 48.5, 49.7 | 39 | 44.0 | 42.2, 47.2 | −5.1 | ||||
| Bladderc | 51.6 | 51.1, 52.2 | 63 | 46.8 | 44.8, 49.4 | −4.8 | 9 | 40.4 | 32.3, 47.2 | −11.2 |
| Women | 56.9 | 56.3, 57.5 | 34 | 52.8 | 51.4, 54.0 | −4.2 | ||||
| Men | 48.7 | 48.2, 49.3 | 25 | 43.3 | 41.3, 45.8 | −5.3 | 6 | 32.3 | 27.5, 44.8 | −16.3 |
| Lung | 52.3 | 51.9, 52.5 | 129 | 48.8 | 48.1, 49.6 | −3.5 | 21 | 47.2 | 45.7, 48.7 | −5.1 |
| Kidney | 52.8 | 52.3, 53.6 | 36 | 47.3 | 45.5, 50.7 | −5.6 | ||||
| Women | 54.8 | 54.3, 55.5 | 21 | 50.0 | 46.8, 52.0 | −4.8 | ||||
| Men | 51.4 | 50.8, 52.1 | 16 | 46.3 | 42.8, 48.8 | −5.1 | ||||
| Prostate | 54.8 | 54.8, 55.0 | 200 | 52.3 | 51.8, 52.7 | −2.6 | 23 | 51.1 | 50.3, 52.0 | −3.8 |
| Leukemia | 55.4 | 54.7, 56.4 | 64 | 49.4 | 47.8, 52.3 | −6.0 | 19 | 41.1 | 38.7, 50.1 | −14.3 |
| Women | 56.8 | 56.0, 57.8 | 25 | 50.4 | 48.8, 53.3 | −6.4 | 14 | 47.5 | 40.3, 51.6 | −9.3 |
| Men | 54.4 | 53.8, 55.3 | 38 | 48.8 | 46.6, 50.8 | −5.6 | 6 | 41.0 | 37.4, 49.3 | −13.4 |
| Skin | 58.0 | 57.4, 58.8 | 62 | 52.6 | 51.2, 54.8 | −5.4 | 8 | 49.8 | 44.6, 54.9 | −8.2 |
| Women | 59.6 | 58.8, 60.4 | 32 | 54.4 | 52.3, 56.9 | −5.2 | ||||
| Men | 56.8 | 56.3, 57.6 | 31 | 51.7 | 50.4, 53.7 | −5.1 | ||||
| Stomach | 58.7 | 58.0, 59.3 | 57 | 54.5 | 52.8, 56.8 | −4.2 | 5 | 44.6 | 43.0, 70.9 | −14.1 |
| Women | 60.8 | 60.0, 61.6 | 28 | 56.8 | 54.8, 59.4 | −3.6 | 5 | 54.5 | 43.5, 70.9 | −6.3 |
| Men | 57.3 | 56.5, 58.0 | 29 | 53.3 | 51.3, 55.5 | −3.1 | ||||
| Pancreas | 59.7 | 59.1, 60.3 | 41 | 56.3 | 54.7, 57.4 | −3.3 | 5 | 52.2 | 50.8, 56.5 | −7.5 |
a
Number of cases that occurred before the age at which the cumulative risk of cancer reaches one per 1000; data are only shown for cancer sites with more than four cases.
b
AD: Age difference to individuals without affected parents/siblings
c
Urinary bladder.
Cancer sites are ordered according to the age at which the cumulative risk of cancer among individuals without a family history reaches one per 1000.
CI, confidence interval; NHL, non-Hodgkin’s lymphoma.