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Agonist-mediated inhibition of basal PRL release in pituitary cells with forskolin-induced elevation of cAMP production. (A) Effects of forskolin and apomorphine on cAMP (top) and PRL (bottom) release. (B) Effects of forskolin and ET-1 on cAMP (top) and PRL (bottom) release. Horizontal bars indicate duration of forskolin treatment and gray areas represent duration of GPCR agonist application. Open circles, cells treated with agonists only.
