TABLE V.
Prediction of growth status during the study using multiple regression
| Coefficient | p-value | lower 95% C.I. | upper 95% C.I. | |
|---|---|---|---|---|
| Height (cm) | ||||
| Disease status (0-control, 1 – sickle cell anemia) | 4.45 | 0.10 | −0.92 | 9.81 |
| Sex (0- female, 1 male) | 0.34 | 0.85 | −3.40 | 4.09 |
| Hemoglobin (g/dL) | 0.23 | 0.59 | −0.61 | 1.07 |
| Total energy expenditure (kcal/kg/day) | −0.37 | <0.001 | −0.53 | −0.20 |
| Tanner stage | 5.81 | <0.001 | 4.78 | 6.83 |
| Weight (kg) | ||||
| Disease status (0-control, 1 – sickle cell anemia) | 2.04 | 0.42 | −2.94 | 7.02 |
| Sex (0- female, 1 male) | 0.92 | 0.60 | −2.54 | 4.37 |
| Hemoglobin (g/dL) | 0.31 | 0.43 | −0.47 | 1.10 |
| TEE (kcal/kg/day) | −0.46 | <0.001 | −0.62 | −0.31 |
| Tanner stage | 5.55 | <0.001 | 4.59 | 6.50 |
| BMI (kg/m2) | ||||
| Disease status (0-control, 1 – sickle cell anemia) | −0.58 | 0.54 | −2.46 | 1.30 |
| Sex (0- female, 1 male) | 0.26 | 0.71 | −1.13 | 1.65 |
| Hemoglobin (g/dL) | 0.03 | 0.83 | −0.25 | 0.31 |
| TEE (kcal/kg/day) | −0.11 | <0.001 | −0.16 | −0.05 |
| Tanner stage | 0.93 | <0.001 | 0.61 | 1.26 |
Models for the longitudinal mixed effects analysis predicting changes in growth over time; Tanner stage (1 to 4) were assessed at each visit and entered into the models as variables; hemoglobin (Hgb) concentration and total energy expenditure (TEE) were measured at each visit (baseline, year 1, and year 2).